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Figure 4 | Comparative Hepatology

Figure 4

From: Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cells

Figure 4

Effect of ET-1 on procollagen type I and TIMP-1 transcript levels of 1st and 4th passage HSC. Cells were incubated without or with 10-8 M or 10-6 M ET-1 for 48 hours. Total RNA from HSC was reverse transcribed and transcript levels of procollagen α1(I) and TIMP-1 were determined by real time quantitative PCR based on the Taqman technology. Data were normalized to GAPDH mRNA levels. Results are given as mean ± SD (n = 4). **: p < 0.01 vs controls.

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Comparative Hepatology

ISSN: 1476-5926