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Table 2 Diagnostic performance of HA in the validation set.

From: Accuracy of hyaluronic acid level for predicting liver fibrosis stages in patients with hepatitis C virus

HA cut-off

Sensitivity (%)

Specificity (%)

NPV (%)

PPV (%)

Population involved (%)

Interpretation

<16

91

36

82

55

24

Absence of fibrosis (F0F1) (82% certainty)

>121

14

99

57

94

7

Presence of fibrosis (F2) (94% certainty)

≤ 25

78

53

89

34

46

Absence of severe fibrosis (F0F1F2) (89% certainty)

>160

22

100

81

100

5

Presence of severe fibrosis (F3) (100% certainty)

≤ 50

100

79

100

20

75

Absence of cirrhosis (F0F1F2F3) (100% certainty)

>237

31

99

96

57

3

Presence of cirrhosis (F4) (57% certainty)

  1. Note 1: Accuracy = Sensitivity + Specificity + NPV + PPV. Note 2: Population involved stands for the proportion of patients who fall in the corresponding cut-off.