Table 3 Summary of the diagnostic value of ActiTest for the diagnosis of necroinflammatory hepatic activity (AUROC) in patients with chronic hepatitis C, from the published studies.
First author, Year | Patient number | Methodology | Marker | Grade/Prevalence | AUROC (SE) | Cut off | Sensitivity | Specificity |
|---|---|---|---|---|---|---|---|---|
Imbert-Bismut, 2001 | 189 | Prospective Single center | ActiTest | A2A3 / 0.33 | 0.79 (0.03) | 0.10 0.30 0.60 0.80 | 0.99 0.91 0.70 0.49 | 0.07 0.42 0.75 0.88 |
Imbert-Bismut, 2001 | 134 | Prospective Single center Validation cohort | ActiTest | A2A3 / 0.28 | 0.75 (0.03) | 0.10 0.30 0.60 0.80 | 1.00 0.94 0.67 0.42 | 0.07 0.33 0.65 0.87 |
Poynard, 2003 | 352 | Retrospective Randomized trial Multicenter Before treatment | ActiTest | A2A3 / 0.83 | 0.75 (0.03) | 0.10 0.30 0.60 0.80 | 1.00 0.90 0.49 0.20 | 0.00 0.38 0.87 0.99 |
Poynard, 2003 | 352 | Retrospective Randomized trial Multicenter After treatment | ActiTest | A2A3 / 0.39 | 0.86 (0.02) | 0.10 0.30 0.60 0.80 | 0.91 0.75 0.38 0.14 | 0.59 0.83 0.98 0.996 |