Figure 1
From: Kupffer and stellate cell proteoglycans mediate malaria sporozoite targeting to the liver
A) Model for sporozoite targeting to and entry into the liver. D = space of Disse, EC = endothelial cell, H = hepatocyte, KC = Kupffer cell, SC = stellate cell, S = sinusoid. B) Model for sporozoite arrest in the sinusoid. Due to their large size and strategic position underneath the endothelial sieve plates, stellate cell-derived ECM proteoglycans may protrude from the space of Disse across the endothelial fenestration into the sinusoidal lumen and thus provide a basis for the parasites to glide towards the next Kupffer cell.