Degree of fibrosis tested | Study | No. | AUC | Cut off used | Sens | Spec | PPV | NPV | LR + (95% CI) | LR – (95% CI) |
---|---|---|---|---|---|---|---|---|---|---|
HA | ||||||||||
Cirrhosis | Oberti [18] (1997) | 109* | n/r | 60mcg/l | 100 | 60 | 78 | 97 | 2.5 (1.7,3.6) | 0.02(0.004,0.18) |
Tran [19] (2000) | 146 | n/r | 60mcg/l | 100 | 86 | 83 | 99 | 6.8 (4.1,11.4) | 0.02 (0.004,0.1) | |
Plevris [21] (2000) | 70 | n/r | 100mcg/l | 87 | 89 | n/a | n/a | 8.0 | 0.15 | |
Stickel [23] (2003) | 87 | 0.78 | 250mcg/l | 100 | 69 | 35 | 98 | 3 (2.0, 4.28) | 0.10 (0.02,0.69) | |
Naveau [25] (2005) | 221 | 0.93 (0.91,0.95) | n/r | n/r | n/r | n/r | n/r | n/r | n/r | |
Nguyen-Khac [28] (2008) | 103 | 0.80 (0.68,0.92_ | n/r | n/r | n/r | n/r | n/r | n/r | n/r | |
Stage 012 vs34 | Stickel [23] (2003) | 87 | 0.76 | 55.5 mcg/l | 83 | 69 | 67 | 83 | 3(1.7, 4.2) | 0.26 (0.13,0.53) |
Nguyen-Khac [28] (2008) | 103 - | 0.83 (0.74-0.92) | ||||||||
Lieber [29] (2008) | 247 | 0.69 | ||||||||
F01vs 234 | Naveau [25] (2005) | 221 | 0.79 (0.76-0.82) | n/r | n/r | n/r | n/r | n/r | n/r | |
Nguyen-Khac [28] (2008) | 103 | 0.80 (0.70-0.92) | n/r | n/r | n/r | n/r | n/r | n/r | n/r | |
Degree of Fibrosis tested | Study | No. | AUC (95%CI) | Cut off used | Sens | Spec | PPV | NPV | LR + (95% CI) | LR-(95% CI) |
F0 vs 1-4 | Nguyen-Khac [28] (2008) | 103 | 0.76 (0.58-0.94) | n/r | n/r | n/r | n/r | n/r | n/r | n/r |
P3NP | ||||||||||
F012 vs34 | Gabrielli [15] (1989) | 44 | n/r | 16 ng/ml | 71 | 50 | n/r | n/r | 1.4 | 0.6 |
Lieber [29] (2008) | 247 | 0.67 | ||||||||
F0 vs F1-6 | Gabriella [15] (1989) | 44 | n/r | 16 ng/ml | 90 | 59 | n/r | n/r | 2 | 0.2 |
Li [17] (1994) | 44 | 0.80 ±0.07 | 1.1 U/ml | 45 | 100 | 94 | 44 | 6.8 (0.99, 47) | 0.6 (0.42, 0.82) | |
Prothrombin Index** | ||||||||||
Cirrhosis | Oberti [18] (1997) | 109 | n/r | 85% | n/r | n/r | n/r | n/r | n/r | n/r |
Croquet [22] (2002) | 240 | n/r | 80% | 81 | 99 | 99 | 85 | 101(14.3,713.5 | 0.2 (0.13,0.28) | |
Tran [19] (2000) | 146 | n/r | 85% | 83 | 93 | 89 | 89 | 12.1(5.56,26.5) | 0.2 (0.1,0.33) | |
TIMP1 | ||||||||||
F012 vs 34(advanced fibrosis) | Lieber [29] (2008) | 247 | 0.68 | n/r | n/r | n/r | n/r | n/r | n/r | |
Any fibrosis (1994) | Li [17] | 44 | 0.96 ±0.03 | 313 ng/ml | n/r | n/r | n/r | n/r | n/r | n/r |
YKL | ||||||||||
Cirrhosis | Tran [19] (2000) | 146 | n/r | 330mcg/l | 51 | 89 | 75 | 74 | 5 (2.4,8.6) | 0.5 (0.4,0.7) |
ApoA1 | ||||||||||
Cirrhosis | Tran [19] (2000) | 146 | n/r | 1.2 g/l | 83 | 93 | 89 | 89 | 12.1 (5.6,26.5) | 0.18 (0.10,0.33) |